Project Summary This is a renewal application to fund lung-related research training at the University of Texas Southwestern Medical Center, at the postdoctoral (MD, PhD) level. The proposal is born out of a collaborative effort between the Pediatric and Adult divisions involved in lung research at this Institute, and is thus interdepartmental at its core. Thirty-three experienced investigators and research mentors representing 13 different clinical and basic science departments and centers form a solid, diverse training force. This funding cycle we have reorganized our mentor groupings from a unidimensional track system into a tridimensional matrix that varies along disease focus, translational level, and scientific competency. Trainees may access their primary and secondary mentors through entry into an appropriate point in the matrix and be encouraged to develop along different axes. This structure encourages cross-disciplinary and trans-departmental training, and creates a framework for professional and scientific development. Trainees will receive a comprehensive field- and project-specific didactic curriculum. Both clinical and basic science trainees will be guided by an individualized advisory committee that has both basic and clinical science mentors, to broaden the trainee?s perspective and facilitate bench to bedside thinking. Emphasis will be placed on maintenance of project focus, creative experimental design, state of the art technology, and early career guidance. The strength of this program lies in the highly collaborative Institutional environment, the unique interdepartmental leadership and training faculty of the program, and the experienced and dedicated faculty serving as trainers.